ML 141
發(fā)布者：信康 瀏覽次數(shù)：
產品名稱:ML 141CAS:71203-35-5別名：ML141;5-(4-甲氧基苯基)-1-(4-氨基磺?；交?-3-苯基-2-吡唑啉英文名：ML 141
- 儲存條件 2-8°C
- 溶解度 DMSO: soluble5mg/mL (warmed, clear solution)
- 顏色white to beige
- 生物活性ML141是Rho家族GTPase cdc42的一種有效的，選擇性可逆非競爭性抑制劑，IC50為200 nM。
- 體外研究ML141 enhances the ability of TMX to suppress BLBC cell growth through both induction of cell death and suppression of cell division. ML141 also significantly protects neuroblastoma cells from metformin-induced apoptosis. Moreover, ML141 diminishes K. pneumoniae invasion in a dose-dependent manner.
- 體內研究In NOD/SCID mice bearing MDA-MB 231 derived tumors, ML141 (1 mg/day i.p.), via inhibition of Cdc42, enables TMX to suppress growth of MDA-MB 231 derived tumors. In addition, ML141 (10 mg/kg i.p.) enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization in mice.
