CCG1423
發(fā)布者：信康 瀏覽次數(shù)：
產(chǎn)品名稱:CCG1423CAS:285986-88-1別名：N-({1-[(4-氯苯基)氨基]-1-氧代-2-丙基}氧基)-3,5-二(三氟甲基)苯甲酰胺;N-[2-[(4-氯苯基)氨基]-1-甲基-2-氧代乙氧基]-3,5-二(三氟甲基)苯甲酰胺英文名：CCG-1423
- 儲(chǔ)存條件 2-8°C
- 溶解度 DMSO: soluble5mg/mL, clear (warmed)
- 顏色white to beige
- 生物活性CCG-1423是一種特定的 RhoA 通路抑制劑，能夠抑制SRF介導(dǎo)的轉(zhuǎn)錄。
- 體外研究CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells. CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity. CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts.
