TAI-1
發(fā)布者：信康 瀏覽次數(shù)：
產(chǎn)品名稱:TAI-1CAS:1334921-03-7別名：英文名：TAI-1
[] - 生物活性TAI-1是一個(gè)有效的特異Hec1抑制劑，會打亂Hec1-Nek2蛋白質(zhì)相互作用。
- 體外研究TAI-1 disrupts the binding of Nek2 to Hec1, which leads to degradation of Nek2 and chromosomal misalignment. TAI-1 shows strong growth inhibitory potency at nM levels across a broad spectrum of tumor cells, and produces synergistic activity with doxorubicin, topotecan and paclitaxel in leukemia, breast and liver cancer cells.
- 體內(nèi)研究TAI-1 (20 mg/kg i.v. or 150 mg/kg p.o.) causes significant tumor growth delay in Huh-7 model and modest tumor inhibition in Colo205 and MDA-MB-231 models.
