PAC1
發(fā)布者：信康 瀏覽次數(shù)：
產(chǎn)品名稱:PAC1CAS:315183-21-2別名：4-(苯基甲基)-1-哌嗪乙酸2-[[2-羥基-3-(2-烯丙-1-基)苯基]亞甲基]酰肼;PAC1(4-(苯基甲基)-1-哌嗪乙酸2-[[2-羥基-3-(2-烯丙-1-基)苯基]亞甲基]酰肼);PAC-110MG;PAC-1,一種酶原-3激活劑英文名：PAC1
- 密度 1.14
- 儲(chǔ)存條件 Store at +4°C
- 溶解度 DMSO: ≥10mg/mL
- 顏色white
- 用途 PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 渭M and caspase 7= 4.5 渭M. The IC50 for apoptosis induction = 0.92 渭M. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
